Rank	Discovery / Scientific Entity	Domain	NASA TRL	SMS Score	30D Delta	Key Institutions	Replication	Lifecycle
#1-1	CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator Dr. Feng Zhang, Dr. Omar Abudayyeh•10.1126/science.aba9381	Synthetic Biology & Genomics	TRL 7	985.3	+24.7%	Broad Institute of MIT, Harvard	99/100	⭐ COMMERCIAL SPINOUT
#2-1	Prime Editing 3b Non-Viral Genomic Correction Dr. David Liu, Dr. Andrew Anzalone•10.1038/s41587-023-01928-y	Synthetic Biology & Genomics	TRL 6	979.0	+53.2%	Harvard University, Broad Institute	98/100	🔬 TRL 4-6
#3+1	Synthetic Yeast Genome Sc2.0 (16-Chromosome) Dr. Jef Boeke, Dr. Patrick Cai•10.1016/j.cell.2023.10.015	Synthetic Biology & Genomics	TRL 6	972.1	+51.7%	Sc2.0 International Consortium, NYU	97/100	📈 SCALING
#4—	Cell-Free Continuous Biomanufacturing Reactor Dr. Michael Jewett, Dr. Jason Kelly•10.1038/s41467-023-41289-w	Synthetic Biology & Genomics	TRL 6	965.8	+15.1%	Northwestern University, Ginkgo Bioworks	98/100	🔬 TRL 4-6
#5-1	Bacteriophage Generative Engineering Platform Dr. Stanley Qi, Dr. Xavier Duportet•10.1038/s41587-024-02189-1	Synthetic Biology & Genomics	TRL 6	960.3	+37.9%	Stanford, Eligo Bioscience	94/100	📈 SCALING
#6—	mRNA-LNP Multivalent Universal Influenza & Corona Vaccine Dr. Drew Weissman, Dr. Katalin Karikó•10.1126/science.abm0271	Synthetic Biology & Genomics	TRL 8	955.5	+13.0%	Penn Medicine	98/100	📈 SCALING
#7—	Engineered Nitrogen-Fixing Endophytic Microbes Dr. Christopher Voigt, Dr. Karsten Temme•10.1073/pnas.2309182120	Synthetic Biology & Genomics	TRL 9	949.0	+39.7%	MIT, Pivot Bio	95/100	📈 SCALING
#8+1	Epigenetic Age Reversal OSK Reprogramming Vector Dr. David Sinclair, Dr. Lu Wang•10.1038/s41586-020-2975-4	Synthetic Biology & Genomics	TRL 6	943.1	+18.4%	Harvard Medical School	98/100	📈 SCALING
#9+4	Universal Off-The-Shelf Allogeneic CAR-T Platform Dr. Waseem Qasim, Dr. Rachel Haurwitz•10.1038/s41591-023-02501-x	Synthetic Biology & Genomics	TRL 8	939.1	+42.3%	UCL, Caribou Biosciences	95/100	🔬 TRL 4-6
#10-2	Enzymatic Carbon Fixation Cycle (CETCH 2.0) Dr. Tobias Erb, Dr. Nicole Paczia•10.1126/science.aah5237	Synthetic Biology & Genomics	TRL 6	933.5	+12.7%	Max Planck Institute for Terrestrial Microbiology	92/100	🔬 TRL 4-6
#11—	Aquila 256-Neutral-Atom Quantum Processor Dr. Mikhail Lukin, Dr. Vladan Vuletic•10.1038/s41586-023-06927-3	Quantum Computing	TRL 7	925.2	+33.7%	QuEra Computing, Harvard	94/100	⭐ COMMERCIAL SPINOUT
#12—	Condor 1,121-Qubit Superconducting Quantum Chip Dr. Jay Gambetta, Dr. Jerry Chow•10.1103/PhysRevX.14.011005	Quantum Computing	TRL 8	919.5	+16.7%	IBM Quantum	96/100	🔬 TRL 4-6
#13+1	Sycamore Topological Surface Code Architecture Dr. Hartmut Neven, Dr. Julian Kelly•10.1038/s41586-022-05434-1	Quantum Computing	TRL 6	915.2	+49.9%	Google Quantum AI	94/100	📈 SCALING
#14—	Photonic Fault-Tolerant Silicon Qubit Architecture Dr. Jeremy O'Brien, Dr. Terry Rudolph•10.1126/science.adg8761	Quantum Computing	TRL 7	909.6	+44.0%	PsiQuantum, SLAC	94/100	⭐ COMMERCIAL SPINOUT
#15+2	Trapped-Ion H2-1 Quantum Computer (56 Qubits) Dr. Ilyas Khan, Dr. Charlie Baldwin•arXiv:2406.02501	Quantum Computing	TRL 7	902.4	+35.0%	Quantinuum	94/100	📈 SCALING
#16+2	Majorana Zero-Mode Topological Qubit Core Dr. Chetan Nayak, Dr. Leo Kouwenhoven•10.1103/PhysRevB.107.245423	Quantum Computing	TRL 5	896.2	+10.0%	Microsoft Quantum, Delft	97/100	⭐ COMMERCIAL SPINOUT
#17+1	Silicon Spin Qubit Bilayer Heterostructure Dr. Michelle Simmons, Dr. Andrea Morello•10.1038/s41565-023-01452-9	Quantum Computing	TRL 5	891.6	+26.0%	UNSW Sydney, Silicon Quantum Computing	96/100	⚡ LAB PROOF
#18+1	Diamond NV-Center Quantum Repeater Network Dr. Ronald Hanson, Dr. Marko Loncar•10.1038/s41586-021-03505-3	Quantum Computing	TRL 4	885.5	+26.8%	Delft QuTech, Harvard	93/100	⚡ LAB PROOF
#19-1	Superconducting Fluxonium Qubit Circuitry Dr. Andrew Houck, Dr. Michel Devoret•10.1103/PRXQuantum.4.040301	Quantum Computing	TRL 5	880.3	+15.8%	Princeton University, Yale	95/100	🔬 TRL 4-6
#20+1	Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II) Dr. Rich Uhlig, Dr. Stefano Pellerano•10.1109/JSSC.2023.3289012	Quantum Computing	TRL 7	874.7	+20.3%	Intel Labs, TU Delft	96/100	⚡ LAB PROOF
#21+1	Room-Temperature Ambient Superconductor Candidate Search (LK-Engine) Dr. Mikhail Eremets, Dr. Anand Bhattacharya•10.1038/s41586-023-06673-4	Advanced Materials & Nanotech	TRL 4	869.1	+13.9%	Max Planck Institute for Solid State Research, Argonne	97/100	⚡ LAB PROOF
#22-1	Magic-Angle Twisted Bilayer Graphene Correlated Superlattices Dr. Pablo Jarillo-Herrero, Dr. Philip Kim•10.1038/nature26160	Advanced Materials & Nanotech	TRL 6	862.7	+32.2%	MIT, Harvard	92/100	🔬 TRL 4-6
#23-3	Synthetic Diamond Wafer Semiconductor Substrates (100mm) Dr. Martin Kuball, Dr. Christoph Nebel•10.1002/pssa.202300451	Advanced Materials & Nanotech	TRL 8	857.9	+42.6%	Diamond Foundry, Fraunhofer IAF	92/100	🔬 TRL 4-6
#24+1	Direct Air Capture Metal-Organic Frameworks (CALF-20) Dr. George Shimizu, Dr. Brett Carter•10.1126/science.abi7281	Advanced Materials & Nanotech	TRL 8	850.9	+42.7%	University of Calgary, Svante	91/100	⚡ LAB PROOF
#25+2	Self-Healing Vascular Polymeric Structural Composites Dr. Nancy Sottos, Dr. Jeffrey Moore•10.1038/s41563-023-01602-x	Advanced Materials & Nanotech	TRL 7	845.5	+20.9%	UIUC, Autonomous Materials Systems	92/100	⭐ COMMERCIAL SPINOUT
#26+2	MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes Dr. Yury Gogotsi, Dr. Michael Naguib•10.1038/s41578-022-00465-1	Advanced Materials & Nanotech	TRL 8	839.4	+9.6%	Drexel University	92/100	⭐ COMMERCIAL SPINOUT
#27+3	Metamaterial Acoustic / Optical Cloaking Hyperlens Dr. Xiang Zhang, Dr. Sir John Pendry•10.1126/science.1147231	Advanced Materials & Nanotech	TRL 4	832.0	+46.6%	UC Berkeley, Oxford	95/100	⭐ COMMERCIAL SPINOUT
#28-2	Aerogel Thermal Barrier (Silica-Polyimide Nanofoam) Dr. Mary Ann Meador, Dr. Stephanie Vivod•10.1021/acsami.2c19012	Advanced Materials & Nanotech	TRL 8	828.7	+9.7%	NASA Glenn, Blueshift Materials	94/100	⚡ LAB PROOF
#29—	Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction Dr. Yadong Li, Dr. Matteo Cargnello•10.1038/s41570-023-00492-3	Advanced Materials & Nanotech	TRL 5	820.8	+48.5%	Tsinghua University, Stanford	94/100	⭐ COMMERCIAL SPINOUT
#30+1	Carbon Nanotube Field-Effect Transistor (RV16X-NANO) Dr. Max Shulaker, Dr. Gage Hills•10.1038/s41586-019-1493-0	Advanced Materials & Nanotech	TRL 5	816.0	+32.8%	MIT, Analog Devices	96/100	⭐ COMMERCIAL SPINOUT
#31-1	AlphaFold 3 Biomolecular Structure Engine Dr. Demis Hassabis, Dr. John Jumper•10.1038/s41586-024-07487-w	AI for Science	TRL 8	809.3	+13.7%	DeepMind, Isomorphic Labs	96/100	⚡ LAB PROOF
#32+1	ESM-3 98B Generative Biology Foundation Model Dr. Alexander Rives, Dr. Tom Sercu•arXiv:2406.20092	AI for Science	TRL 5	804.4	+44.7%	EvolutionaryScale	93/100	⭐ COMMERCIAL SPINOUT
#33+1	GNoME Materials Discovery Graph Network Dr. Amil Merchant, Dr. Ekin Dogus Cubuk•10.1038/s41586-023-06735-9	AI for Science	TRL 6	799.4	+11.8%	Google DeepMind	91/100	🔬 TRL 4-6
#34—	RFdiffusion De Novo Protein Generator Dr. David Baker, Dr. Joseph Watson•10.1038/s41586-023-06415-8	AI for Science	TRL 6	792.8	+14.7%	Institute for Protein Design (UW)	94/100	⭐ COMMERCIAL SPINOUT
#35-2	GraphCast Global 10-Day AI Weather Forecaster Dr. Remi Lam, Dr. Ferran Alet•10.1126/science.adi2336	AI for Science	TRL 7	787.9	+32.1%	Google DeepMind, ECMWF	93/100	🔬 TRL 4-6
#36-1	DeepPotential Molecular Dynamics (DP-MD) Dr. Weinan E, Dr. Linfeng Zhang•arXiv:2308.12001	AI for Science	TRL 7	781.5	+13.8%	AI for Science Institute (AISI)	89/100	⚡ LAB PROOF
#37—	AlphaGeometry Automated Olympiad Geometry Solver Dr. Trieu Trinh, Dr. Thang Luong•10.1038/s41586-023-06747-5	AI for Science	TRL 6	774.3	+9.9%	Google DeepMind	94/100	⚡ LAB PROOF
#38-1	BioNeMo Generative Drug Discovery Supercomputing Dr. Kimberly Powell, Dr. Rory Kelleher•10.1109/MCSE.2024.33	AI for Science	TRL 7	770.9	+18.4%	NVIDIA, Genentech	92/100	🔬 TRL 4-6
#39—	Orbital-Net Physics-Informed Spacecraft Autonomy Dr. Soon-Jo Chung, Dr. Richard Murray•10.2514/1.G007123	AI for Science	TRL 6	763.5	+31.4%	Caltech JPL, MIT AeroAstro	95/100	🔬 TRL 4-6
#40—	OpenFold Open-Source Trainable AlphaFold2 Dr. Mohammed AlQuraishi, Dr. Gustaf Ahdritz•10.1038/s41592-024-02206-8	AI for Science	TRL 8	756.5	+32.7%	Columbia University, Prescient Design	91/100	🔬 TRL 4-6
#41-2	N1 1024-Channel Flexible Thread Intracortical BCI Dr. Matthew MacDougall, Dr. DJ Seo•10.2196/16194	Neuroscience & Brain Interfaces	TRL 7	752.0	+27.6%	Neuralink	92/100	⚡ LAB PROOF
#42-2	Layer 7 Micro-Electrocorticography (uECoG) Thin-Film Array Dr. Benjamin Rapoport, Dr. Mark Richardson•10.1038/s41551-023-01089-w	Neuroscience & Brain Interfaces	TRL 8	747.8	+31.9%	Precision Neuroscience, Mount Sinai	91/100	⭐ COMMERCIAL SPINOUT
#43-3	Stentrode Endovascular Brain-Computer Interface Dr. Thomas Oxley, Dr. Nicholas Opie•10.1001/jamaneurol.2022.4847	Neuroscience & Brain Interfaces	TRL 8	741.6	+39.2%	Synchron, Melbourne University	93/100	⭐ COMMERCIAL SPINOUT
#44-2	Neural Replay Non-Invasive Continuous Speech Decoder Dr. Alexander Huth, Dr. Jerry Tang•10.1038/s41593-023-01304-9	Neuroscience & Brain Interfaces	TRL 5	735.8	+25.9%	UT Austin	94/100	⭐ COMMERCIAL SPINOUT
#45—	Whole-Brain Synaptic Connectome Imaging (MICrONS) Dr. Jeff Lichtman, Dr. Clay Reid•10.1101/2021.07.28.454025	Neuroscience & Brain Interfaces	TRL 6	728.7	+34.0%	Harvard, Allen Institute, Princeton	90/100	🔬 TRL 4-6
#46+1	Closed-Loop Deep Brain Stimulator (Percept PC Sensing) Dr. Philip Starr, Dr. Edward Chang•10.1038/s41587-021-00897-4	Neuroscience & Brain Interfaces	TRL 8	722.4	+16.5%	Medtronic, UCSF	90/100	🔬 TRL 4-6
#47—	Optogenetic Cortical Restoration of Vision Dr. Jose-Alain Sahel, Dr. Botond Roska•10.1038/s41591-021-01351-4	Neuroscience & Brain Interfaces	TRL 6	718.4	+23.2%	Institut de la Vision, GenSight	88/100	🔬 TRL 4-6
#48—	Organoid Intelligence (OI) Brain-on-Chip Biocomputer Dr. Thomas Hartung, Dr. Brett Kagan•10.3389/fsci.2023.1017235	Neuroscience & Brain Interfaces	TRL 4	711.1	+36.8%	Johns Hopkins, Cortical Labs	90/100	⚡ LAB PROOF
#49-1	Focused Ultrasound Blood-Brain Barrier Opening System Dr. Kullervo Hynynen, Dr. Nir Lipsman•10.1038/s41467-023-38823-1	Neuroscience & Brain Interfaces	TRL 8	705.4	+26.3%	Sunnybrook, Insightec	90/100	⭐ COMMERCIAL SPINOUT
#50-1	Spinal Cord Neuroprosthetic Epidural Stimulation Dr. Gregoire Courtine, Dr. Jocelyne Bloch•10.1038/s41586-023-06094-5	Neuroscience & Brain Interfaces	TRL 7	701.0	+10.2%	EPFL, Lausanne University Hospital	91/100	⭐ COMMERCIAL SPINOUT

#1-1

CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator

10.1126/science.aba9381

SMS Score

985.3 /1000

30D Surge

+24.7%

NASA TRL

TRL 7

Domain

Synthetic Biology & Genomics

#2-1

Prime Editing 3b Non-Viral Genomic Correction

10.1038/s41587-023-01928-y

SMS Score

979.0 /1000

30D Surge

+53.2%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#3+1

Synthetic Yeast Genome Sc2.0 (16-Chromosome)

10.1016/j.cell.2023.10.015

SMS Score

972.1 /1000

30D Surge

+51.7%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#4—

Cell-Free Continuous Biomanufacturing Reactor

10.1038/s41467-023-41289-w

SMS Score

965.8 /1000

30D Surge

+15.1%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#5-1

Bacteriophage Generative Engineering Platform

10.1038/s41587-024-02189-1

SMS Score

960.3 /1000

30D Surge

+37.9%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#6—

mRNA-LNP Multivalent Universal Influenza & Corona Vaccine

10.1126/science.abm0271

SMS Score

955.5 /1000

30D Surge

+13.0%

NASA TRL

TRL 8

Domain

Synthetic Biology & Genomics

#7—

Engineered Nitrogen-Fixing Endophytic Microbes

10.1073/pnas.2309182120

SMS Score

949.0 /1000

30D Surge

+39.7%

NASA TRL

TRL 9

Domain

Synthetic Biology & Genomics

#8+1

Epigenetic Age Reversal OSK Reprogramming Vector

10.1038/s41586-020-2975-4

SMS Score

943.1 /1000

30D Surge

+18.4%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#9+4

Universal Off-The-Shelf Allogeneic CAR-T Platform

10.1038/s41591-023-02501-x

SMS Score

939.1 /1000

30D Surge

+42.3%

NASA TRL

TRL 8

Domain

Synthetic Biology & Genomics

#10-2

Enzymatic Carbon Fixation Cycle (CETCH 2.0)

10.1126/science.aah5237

SMS Score

933.5 /1000

30D Surge

+12.7%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#11—

Aquila 256-Neutral-Atom Quantum Processor

10.1038/s41586-023-06927-3

SMS Score

925.2 /1000

30D Surge

+33.7%

NASA TRL

TRL 7

Domain

Quantum Computing

#12—

Condor 1,121-Qubit Superconducting Quantum Chip

10.1103/PhysRevX.14.011005

SMS Score

919.5 /1000

30D Surge

+16.7%

NASA TRL

TRL 8

Domain

Quantum Computing

#13+1

Sycamore Topological Surface Code Architecture

10.1038/s41586-022-05434-1

SMS Score

915.2 /1000

30D Surge

+49.9%

NASA TRL

TRL 6

Domain

Quantum Computing

#14—

Photonic Fault-Tolerant Silicon Qubit Architecture

10.1126/science.adg8761

SMS Score

909.6 /1000

30D Surge

+44.0%

NASA TRL

TRL 7

Domain

Quantum Computing

#15+2

Trapped-Ion H2-1 Quantum Computer (56 Qubits)

arXiv:2406.02501

SMS Score

902.4 /1000

30D Surge

+35.0%

NASA TRL

TRL 7

Domain

Quantum Computing

#16+2

Majorana Zero-Mode Topological Qubit Core

10.1103/PhysRevB.107.245423

SMS Score

896.2 /1000

30D Surge

+10.0%

NASA TRL

TRL 5

Domain

Quantum Computing

#17+1

Silicon Spin Qubit Bilayer Heterostructure

10.1038/s41565-023-01452-9

SMS Score

891.6 /1000

30D Surge

+26.0%

NASA TRL

TRL 5

Domain

Quantum Computing

#18+1

Diamond NV-Center Quantum Repeater Network

10.1038/s41586-021-03505-3

SMS Score

885.5 /1000

30D Surge

+26.8%

NASA TRL

TRL 4

Domain

Quantum Computing

#19-1

Superconducting Fluxonium Qubit Circuitry

10.1103/PRXQuantum.4.040301

SMS Score

880.3 /1000

30D Surge

+15.8%

NASA TRL

TRL 5

Domain

Quantum Computing

#20+1

Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II)

10.1109/JSSC.2023.3289012

SMS Score

874.7 /1000

30D Surge

+20.3%

NASA TRL

TRL 7

Domain

Quantum Computing

#21+1

Room-Temperature Ambient Superconductor Candidate Search (LK-Engine)

10.1038/s41586-023-06673-4

SMS Score

869.1 /1000

30D Surge

+13.9%

NASA TRL

TRL 4

Domain

Advanced Materials & Nanotech

#22-1

Magic-Angle Twisted Bilayer Graphene Correlated Superlattices

10.1038/nature26160

SMS Score

862.7 /1000

30D Surge

+32.2%

NASA TRL

TRL 6

Domain

Advanced Materials & Nanotech

#23-3

Synthetic Diamond Wafer Semiconductor Substrates (100mm)

10.1002/pssa.202300451

SMS Score

857.9 /1000

30D Surge

+42.6%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#24+1

Direct Air Capture Metal-Organic Frameworks (CALF-20)

10.1126/science.abi7281

SMS Score

850.9 /1000

30D Surge

+42.7%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#25+2

Self-Healing Vascular Polymeric Structural Composites

10.1038/s41563-023-01602-x

SMS Score

845.5 /1000

30D Surge

+20.9%

NASA TRL

TRL 7

Domain

Advanced Materials & Nanotech

#26+2

MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes

10.1038/s41578-022-00465-1

SMS Score

839.4 /1000

30D Surge

+9.6%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#27+3

Metamaterial Acoustic / Optical Cloaking Hyperlens

10.1126/science.1147231

SMS Score

832.0 /1000

30D Surge

+46.6%

NASA TRL

TRL 4

Domain

Advanced Materials & Nanotech

#28-2

Aerogel Thermal Barrier (Silica-Polyimide Nanofoam)

10.1021/acsami.2c19012

SMS Score

828.7 /1000

30D Surge

+9.7%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#29—

Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction

10.1038/s41570-023-00492-3

SMS Score

820.8 /1000

30D Surge

+48.5%

NASA TRL

TRL 5

Domain

Advanced Materials & Nanotech

#30+1

Carbon Nanotube Field-Effect Transistor (RV16X-NANO)

10.1038/s41586-019-1493-0

SMS Score

816.0 /1000

30D Surge

+32.8%

NASA TRL

TRL 5

Domain

Advanced Materials & Nanotech

#31-1

AlphaFold 3 Biomolecular Structure Engine

10.1038/s41586-024-07487-w

SMS Score

809.3 /1000

30D Surge

+13.7%

NASA TRL

TRL 8

Domain

AI for Science

#32+1

ESM-3 98B Generative Biology Foundation Model

arXiv:2406.20092

SMS Score

804.4 /1000

30D Surge

+44.7%

NASA TRL

TRL 5

Domain

AI for Science

#33+1

GNoME Materials Discovery Graph Network

10.1038/s41586-023-06735-9

SMS Score

799.4 /1000

30D Surge

+11.8%

NASA TRL

TRL 6

Domain

AI for Science

#34—

RFdiffusion De Novo Protein Generator

10.1038/s41586-023-06415-8

SMS Score

792.8 /1000

30D Surge

+14.7%

NASA TRL

TRL 6

Domain

AI for Science

#35-2

GraphCast Global 10-Day AI Weather Forecaster

10.1126/science.adi2336

SMS Score

787.9 /1000

30D Surge

+32.1%

NASA TRL

TRL 7

Domain

AI for Science

#36-1

DeepPotential Molecular Dynamics (DP-MD)

arXiv:2308.12001

SMS Score

781.5 /1000

30D Surge

+13.8%

NASA TRL

TRL 7

Domain

AI for Science

#37—

AlphaGeometry Automated Olympiad Geometry Solver

10.1038/s41586-023-06747-5

SMS Score

774.3 /1000

30D Surge

+9.9%

NASA TRL

TRL 6

Domain

AI for Science

#38-1

BioNeMo Generative Drug Discovery Supercomputing

10.1109/MCSE.2024.33

SMS Score

770.9 /1000

30D Surge

+18.4%

NASA TRL

TRL 7

Domain

AI for Science

#39—

Orbital-Net Physics-Informed Spacecraft Autonomy

10.2514/1.G007123

SMS Score

763.5 /1000

30D Surge

+31.4%

NASA TRL

TRL 6

Domain

AI for Science

#40—

OpenFold Open-Source Trainable AlphaFold2

10.1038/s41592-024-02206-8

SMS Score

756.5 /1000

30D Surge

+32.7%

NASA TRL

TRL 8

Domain

AI for Science

#41-2

N1 1024-Channel Flexible Thread Intracortical BCI

10.2196/16194

SMS Score

752.0 /1000

30D Surge

+27.6%

NASA TRL

TRL 7

Domain

Neuroscience & Brain Interfaces

#42-2

Layer 7 Micro-Electrocorticography (uECoG) Thin-Film Array

10.1038/s41551-023-01089-w

SMS Score

747.8 /1000

30D Surge

+31.9%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#43-3

Stentrode Endovascular Brain-Computer Interface

10.1001/jamaneurol.2022.4847

SMS Score

741.6 /1000

30D Surge

+39.2%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#44-2

Neural Replay Non-Invasive Continuous Speech Decoder

10.1038/s41593-023-01304-9

SMS Score

735.8 /1000

30D Surge

+25.9%

NASA TRL

TRL 5

Domain

Neuroscience & Brain Interfaces

#45—

Whole-Brain Synaptic Connectome Imaging (MICrONS)

10.1101/2021.07.28.454025

SMS Score

728.7 /1000

30D Surge

+34.0%

NASA TRL

TRL 6

Domain

Neuroscience & Brain Interfaces

#46+1

Closed-Loop Deep Brain Stimulator (Percept PC Sensing)

10.1038/s41587-021-00897-4

SMS Score

722.4 /1000

30D Surge

+16.5%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#47—

Optogenetic Cortical Restoration of Vision

10.1038/s41591-021-01351-4

SMS Score

718.4 /1000

30D Surge

+23.2%

NASA TRL

TRL 6

Domain

Neuroscience & Brain Interfaces

#48—

Organoid Intelligence (OI) Brain-on-Chip Biocomputer

10.3389/fsci.2023.1017235

SMS Score

711.1 /1000

30D Surge

+36.8%

NASA TRL

TRL 4

Domain

Neuroscience & Brain Interfaces

#49-1

Focused Ultrasound Blood-Brain Barrier Opening System

10.1038/s41467-023-38823-1

SMS Score

705.4 /1000

30D Surge

+26.3%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#50-1

Spinal Cord Neuroprosthetic Epidural Stimulation

10.1038/s41586-023-06094-5

SMS Score

701.0 /1000

30D Surge

+10.2%

NASA TRL

TRL 7

Domain

Neuroscience & Brain Interfaces

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CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator

Prime Editing 3b Non-Viral Genomic Correction

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Cell-Free Continuous Biomanufacturing Reactor

Bacteriophage Generative Engineering Platform

mRNA-LNP Multivalent Universal Influenza & Corona Vaccine

Engineered Nitrogen-Fixing Endophytic Microbes

Epigenetic Age Reversal OSK Reprogramming Vector

Universal Off-The-Shelf Allogeneic CAR-T Platform

Enzymatic Carbon Fixation Cycle (CETCH 2.0)

Aquila 256-Neutral-Atom Quantum Processor

Condor 1,121-Qubit Superconducting Quantum Chip

Sycamore Topological Surface Code Architecture

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Trapped-Ion H2-1 Quantum Computer (56 Qubits)

Majorana Zero-Mode Topological Qubit Core

Silicon Spin Qubit Bilayer Heterostructure

Diamond NV-Center Quantum Repeater Network

Superconducting Fluxonium Qubit Circuitry

Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II)

Room-Temperature Ambient Superconductor Candidate Search (LK-Engine)

Magic-Angle Twisted Bilayer Graphene Correlated Superlattices

Synthetic Diamond Wafer Semiconductor Substrates (100mm)

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Metamaterial Acoustic / Optical Cloaking Hyperlens

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AlphaFold 3 Biomolecular Structure Engine

ESM-3 98B Generative Biology Foundation Model

GNoME Materials Discovery Graph Network

RFdiffusion De Novo Protein Generator

GraphCast Global 10-Day AI Weather Forecaster

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BioNeMo Generative Drug Discovery Supercomputing

Orbital-Net Physics-Informed Spacecraft Autonomy

OpenFold Open-Source Trainable AlphaFold2

N1 1024-Channel Flexible Thread Intracortical BCI

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Whole-Brain Synaptic Connectome Imaging (MICrONS)

Closed-Loop Deep Brain Stimulator (Percept PC Sensing)

Optogenetic Cortical Restoration of Vision

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Focused Ultrasound Blood-Brain Barrier Opening System

Spinal Cord Neuroprosthetic Epidural Stimulation

Unlock Full Top 100 Scientific Indices (#51–#100)