COMMERCIAL SPINOUTS100 Monitored Entities9-Vector SMS TelemetryNASA TRL 1–9

DeepTech & HardTech Spinouts 100

Commercial spinouts and venture-funded hard-tech startups commercializing fusion, quantum computing, synthetic biology, and advanced materials.

Master SMS Equation: $$\text{SMS} = 200 R_{\text{momentum}} + 150 N_{\text{novelty}} + 150 V_{\text{validation}} + 100 L_{\text{activity}} + 100 F_{\text{funding}} + 100 P_{\text{patents}} + 100 A_{\text{adoption}} + 50 S_{\text{attention}} + 50 C_{\text{commercial}}$$
Derivation
#1—

SPARC High-Field HTS Tokamak Fusion Core

10.1017/S002237782000122X
SMS Score
982.9 /1000
30D Surge
+46.5%
NASA TRL
TRL 6
Domain
Nuclear Fusion & Clean Energy
#2—

National Ignition Facility Target Chamber (Net Gain 3.88 MJ)

10.1103/PhysRevLett.132.065102
SMS Score
977.1 /1000
30D Surge
+13.9%
NASA TRL
TRL 6
Domain
Nuclear Fusion & Clean Energy
#3-3

Polaris Magneto-Inertial Direct Energy Recovery Reactor

arXiv:2311.14002
SMS Score
973.9 /1000
30D Surge
+61.4%
NASA TRL
TRL 6
Domain
Nuclear Fusion & Clean Energy
#4+2

Sheared-Flow Stabilized Z-Pinch FuZE-Q Chamber

10.1103/PhysRevLett.128.145001
SMS Score
967.7 /1000
30D Surge
+36.4%
NASA TRL
TRL 6
Domain
Nuclear Fusion & Clean Energy
#5+3

Perovskite-Silicon Tandem Photovoltaic Cell (33.9% Efficiency)

10.1038/s41560-023-01378-0
SMS Score
962.1 /1000
30D Surge
+8.6%
NASA TRL
TRL 7
Domain
Nuclear Fusion & Clean Energy
#6—

Solid-State Lithium-Metal Electrolyte Anode

10.1038/s41560-022-01124-x
SMS Score
954.8 /1000
30D Surge
+12.7%
NASA TRL
TRL 8
Domain
Nuclear Fusion & Clean Energy
#7-1

Iron-Air Multi-Day Grid Storage Battery (100-Hour)

10.1149/1945-7111/ac8221
SMS Score
949.0 /1000
30D Surge
+53.1%
NASA TRL
TRL 9
Domain
Nuclear Fusion & Clean Energy
#8-1

Solid Oxide Electrolyzer Cell (SOEC) Green Hydrogen

10.1038/s41578-023-00589-2
SMS Score
943.2 /1000
30D Surge
+35.8%
NASA TRL
TRL 9
Domain
Nuclear Fusion & Clean Energy
#9-1

Sodium-Ion Prismatic Power Cell (160 Wh/kg)

10.1002/aenm.202301901
SMS Score
938.0 /1000
30D Surge
+55.5%
NASA TRL
TRL 9
Domain
Nuclear Fusion & Clean Energy
#10+1

Natrium Sodium-Cooled Fast Reactor with Molten Salt Storage

10.1016/j.nucengdes.2023.112450
SMS Score
931.7 /1000
30D Surge
+22.5%
NASA TRL
TRL 7
Domain
Nuclear Fusion & Clean Energy
#11-1

Aquila 256-Neutral-Atom Quantum Processor

10.1038/s41586-023-06927-3
SMS Score
925.8 /1000
30D Surge
+28.2%
NASA TRL
TRL 7
Domain
Quantum Computing
#12+4

Condor 1,121-Qubit Superconducting Quantum Chip

10.1103/PhysRevX.14.011005
SMS Score
920.0 /1000
30D Surge
+22.4%
NASA TRL
TRL 7
Domain
Quantum Computing
#13+2

Sycamore Topological Surface Code Architecture

10.1038/s41586-022-05434-1
SMS Score
913.7 /1000
30D Surge
+7.4%
NASA TRL
TRL 6
Domain
Quantum Computing
#14+1

Photonic Fault-Tolerant Silicon Qubit Architecture

10.1126/science.adg8761
SMS Score
909.9 /1000
30D Surge
+30.9%
NASA TRL
TRL 6
Domain
Quantum Computing
#15+1

Trapped-Ion H2-1 Quantum Computer (56 Qubits)

arXiv:2406.02501
SMS Score
901.7 /1000
30D Surge
+41.0%
NASA TRL
TRL 7
Domain
Quantum Computing
#16+4

Majorana Zero-Mode Topological Qubit Core

10.1103/PhysRevB.107.245423
SMS Score
898.5 /1000
30D Surge
+22.7%
NASA TRL
TRL 4
Domain
Quantum Computing
#17—

Silicon Spin Qubit Bilayer Heterostructure

10.1038/s41565-023-01452-9
SMS Score
892.4 /1000
30D Surge
+9.7%
NASA TRL
TRL 6
Domain
Quantum Computing
#18+1

Diamond NV-Center Quantum Repeater Network

10.1038/s41586-021-03505-3
SMS Score
884.6 /1000
30D Surge
+33.3%
NASA TRL
TRL 6
Domain
Quantum Computing
#19+1

Superconducting Fluxonium Qubit Circuitry

10.1103/PRXQuantum.4.040301
SMS Score
879.7 /1000
30D Surge
+14.5%
NASA TRL
TRL 4
Domain
Quantum Computing
#20+1

Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II)

10.1109/JSSC.2023.3289012
SMS Score
872.6 /1000
30D Surge
+35.9%
NASA TRL
TRL 8
Domain
Quantum Computing
#21+3

CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator

10.1126/science.aba9381
SMS Score
866.9 /1000
30D Surge
+47.1%
NASA TRL
TRL 7
Domain
Synthetic Biology & Genomics
#22-2

Prime Editing 3b Non-Viral Genomic Correction

10.1038/s41587-023-01928-y
SMS Score
862.0 /1000
30D Surge
+23.9%
NASA TRL
TRL 6
Domain
Synthetic Biology & Genomics
#23—

Synthetic Yeast Genome Sc2.0 (16-Chromosome)

10.1016/j.cell.2023.10.015
SMS Score
855.6 /1000
30D Surge
+34.5%
NASA TRL
TRL 4
Domain
Synthetic Biology & Genomics
#24—

Cell-Free Continuous Biomanufacturing Reactor

10.1038/s41467-023-41289-w
SMS Score
852.0 /1000
30D Surge
+18.2%
NASA TRL
TRL 7
Domain
Synthetic Biology & Genomics
#25—

Bacteriophage Generative Engineering Platform

10.1038/s41587-024-02189-1
SMS Score
846.5 /1000
30D Surge
+42.2%
NASA TRL
TRL 7
Domain
Synthetic Biology & Genomics
#26+4

mRNA-LNP Multivalent Universal Influenza & Corona Vaccine

10.1126/science.abm0271
SMS Score
838.5 /1000
30D Surge
+18.5%
NASA TRL
TRL 8
Domain
Synthetic Biology & Genomics
#27+4

Engineered Nitrogen-Fixing Endophytic Microbes

10.1073/pnas.2309182120
SMS Score
832.9 /1000
30D Surge
+16.0%
NASA TRL
TRL 7
Domain
Synthetic Biology & Genomics
#28—

Epigenetic Age Reversal OSK Reprogramming Vector

10.1038/s41586-020-2975-4
SMS Score
827.6 /1000
30D Surge
+47.5%
NASA TRL
TRL 4
Domain
Synthetic Biology & Genomics
#29-2

Universal Off-The-Shelf Allogeneic CAR-T Platform

10.1038/s41591-023-02501-x
SMS Score
822.3 /1000
30D Surge
+32.6%
NASA TRL
TRL 6
Domain
Synthetic Biology & Genomics
#30—

Enzymatic Carbon Fixation Cycle (CETCH 2.0)

10.1126/science.aah5237
SMS Score
816.8 /1000
30D Surge
+13.4%
NASA TRL
TRL 6
Domain
Synthetic Biology & Genomics
#31-1

Room-Temperature Ambient Superconductor Candidate Search (LK-Engine)

10.1038/s41586-023-06673-4
SMS Score
809.4 /1000
30D Surge
+33.8%
NASA TRL
TRL 5
Domain
Advanced Materials & Nanotech
#32—

Magic-Angle Twisted Bilayer Graphene Correlated Superlattices

10.1038/nature26160
SMS Score
804.5 /1000
30D Surge
+44.7%
NASA TRL
TRL 5
Domain
Advanced Materials & Nanotech
#33+4

Synthetic Diamond Wafer Semiconductor Substrates (100mm)

10.1002/pssa.202300451
SMS Score
799.8 /1000
30D Surge
+35.1%
NASA TRL
TRL 7
Domain
Advanced Materials & Nanotech
#34+2

Direct Air Capture Metal-Organic Frameworks (CALF-20)

10.1126/science.abi7281
SMS Score
793.6 /1000
30D Surge
+23.7%
NASA TRL
TRL 8
Domain
Advanced Materials & Nanotech
#35-1

Self-Healing Vascular Polymeric Structural Composites

10.1038/s41563-023-01602-x
SMS Score
788.3 /1000
30D Surge
+41.2%
NASA TRL
TRL 5
Domain
Advanced Materials & Nanotech
#36+2

MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes

10.1038/s41578-022-00465-1
SMS Score
780.5 /1000
30D Surge
+19.5%
NASA TRL
TRL 7
Domain
Advanced Materials & Nanotech
#37+4

Metamaterial Acoustic / Optical Cloaking Hyperlens

10.1126/science.1147231
SMS Score
774.8 /1000
30D Surge
+38.1%
NASA TRL
TRL 4
Domain
Advanced Materials & Nanotech
#38+2

Aerogel Thermal Barrier (Silica-Polyimide Nanofoam)

10.1021/acsami.2c19012
SMS Score
768.1 /1000
30D Surge
+8.2%
NASA TRL
TRL 8
Domain
Advanced Materials & Nanotech
#39—

Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction

10.1038/s41570-023-00492-3
SMS Score
764.8 /1000
30D Surge
+19.3%
NASA TRL
TRL 6
Domain
Advanced Materials & Nanotech
#40+4

Carbon Nanotube Field-Effect Transistor (RV16X-NANO)

10.1038/s41586-019-1493-0
SMS Score
758.5 /1000
30D Surge
+7.2%
NASA TRL
TRL 6
Domain
Advanced Materials & Nanotech
#41-3

Figure 02 Autonomous Humanoid Neural Robot

arXiv:2407.12301
SMS Score
753.2 /1000
30D Surge
+21.6%
NASA TRL
TRL 7
Domain
Robotics & Bio-mechanics
#42—

Atlas Fully Electric Humanoid Dynamic System

10.1109/TRO.2023.3298102
SMS Score
745.6 /1000
30D Surge
+33.8%
NASA TRL
TRL 7
Domain
Robotics & Bio-mechanics
#43+4

Da Vinci 5 Next-Gen Robotic Surgical Console

10.1097/SLA.0000000000006124
SMS Score
741.4 /1000
30D Surge
+42.0%
NASA TRL
TRL 8
Domain
Robotics & Bio-mechanics
#44-2

Soft Biohybrid Muscle-Actuated Robotic Fish

10.1126/science.abm7864
SMS Score
735.0 /1000
30D Surge
+28.5%
NASA TRL
TRL 4
Domain
Robotics & Bio-mechanics
#45+2

AnySkin Tactile Sensory Matrix for Dexterous Hands

10.1109/ICRA.2024.10611201
SMS Score
727.5 /1000
30D Surge
+13.1%
NASA TRL
TRL 7
Domain
Robotics & Bio-mechanics
#46—

CyberRunner Model-Based RL Bipedal Dynamic Locomotion

10.1038/s42256-023-00774-6
SMS Score
722.6 /1000
30D Surge
+34.7%
NASA TRL
TRL 5
Domain
Robotics & Bio-mechanics
#47+4

Agility Digit Bipedal Logistics Warehouse Fleet

10.1177/02783649231189012
SMS Score
717.4 /1000
30D Surge
+11.8%
NASA TRL
TRL 8
Domain
Robotics & Bio-mechanics
#48—

Bio-Inspired Ornithopter Micro-Aerial Vehicle

10.1126/scirobotics.aat0359
SMS Score
710.6 /1000
30D Surge
+35.1%
NASA TRL
TRL 5
Domain
Robotics & Bio-mechanics
#49—

Modular Robotic Soft Exosuit for Gait Rehabilitation

10.1126/scitranslmed.aai9084
SMS Score
707.0 /1000
30D Surge
+30.1%
NASA TRL
TRL 8
Domain
Robotics & Bio-mechanics
#50-3

Octopus-Inspired Soft Continuum Manipulator

10.1089/soro.2023.0041
SMS Score
699.5 /1000
30D Surge
+7.7%
NASA TRL
TRL 5
Domain
Robotics & Bio-mechanics

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