Rank	Discovery / Scientific Entity	Domain	NASA TRL	SMS Score	30D Delta	Key Institutions	Replication	Lifecycle
#1+3	AlphaFold 3 Biomolecular Structure Engine Dr. Demis Hassabis, Dr. John Jumper•10.1038/s41586-024-07487-w	AI for Science	TRL 9	984.5	+32.4%	DeepMind, Isomorphic Labs	97/100	🔬 TRL 4-6
#2+4	ESM-3 98B Generative Biology Foundation Model Dr. Alexander Rives, Dr. Tom Sercu•arXiv:2406.20092	AI for Science	TRL 6	977.6	+7.0%	EvolutionaryScale	94/100	📈 SCALING
#3—	GNoME Materials Discovery Graph Network Dr. Amil Merchant, Dr. Ekin Dogus Cubuk•10.1038/s41586-023-06735-9	AI for Science	TRL 8	973.1	+45.8%	Google DeepMind	95/100	📈 SCALING
#4—	RFdiffusion De Novo Protein Generator Dr. David Baker, Dr. Joseph Watson•10.1038/s41586-023-06415-8	AI for Science	TRL 8	968.0	+25.8%	Institute for Protein Design (UW)	99/100	📈 SCALING
#5+2	GraphCast Global 10-Day AI Weather Forecaster Dr. Remi Lam, Dr. Ferran Alet•10.1126/science.adi2336	AI for Science	TRL 9	960.5	+9.9%	Google DeepMind, ECMWF	98/100	🔬 TRL 4-6
#6-3	DeepPotential Molecular Dynamics (DP-MD) Dr. Weinan E, Dr. Linfeng Zhang•arXiv:2308.12001	AI for Science	TRL 8	955.1	+38.0%	AI for Science Institute (AISI)	95/100	📈 SCALING
#7+2	AlphaGeometry Automated Olympiad Geometry Solver Dr. Trieu Trinh, Dr. Thang Luong•10.1038/s41586-023-06747-5	AI for Science	TRL 6	948.2	+39.8%	Google DeepMind	93/100	🔬 TRL 4-6
#8-1	BioNeMo Generative Drug Discovery Supercomputing Dr. Kimberly Powell, Dr. Rory Kelleher•10.1109/MCSE.2024.33	AI for Science	TRL 8	944.5	+49.5%	NVIDIA, Genentech	95/100	🔬 TRL 4-6
#9-2	Orbital-Net Physics-Informed Spacecraft Autonomy Dr. Soon-Jo Chung, Dr. Richard Murray•10.2514/1.G007123	AI for Science	TRL 6	939.0	+18.3%	Caltech JPL, MIT AeroAstro	95/100	📈 SCALING
#10—	OpenFold Open-Source Trainable AlphaFold2 Dr. Mohammed AlQuraishi, Dr. Gustaf Ahdritz•10.1038/s41592-024-02206-8	AI for Science	TRL 9	931.9	+29.0%	Columbia University, Prescient Design	94/100	📈 SCALING
#11-3	CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator Dr. Feng Zhang, Dr. Omar Abudayyeh•10.1126/science.aba9381	Synthetic Biology & Genomics	TRL 7	926.4	+38.0%	Broad Institute of MIT, Harvard	95/100	📈 SCALING
#12-3	Prime Editing 3b Non-Viral Genomic Correction Dr. David Liu, Dr. Andrew Anzalone•10.1038/s41587-023-01928-y	Synthetic Biology & Genomics	TRL 6	921.8	+21.3%	Harvard University, Broad Institute	94/100	📈 SCALING
#13+2	Synthetic Yeast Genome Sc2.0 (16-Chromosome) Dr. Jef Boeke, Dr. Patrick Cai•10.1016/j.cell.2023.10.015	Synthetic Biology & Genomics	TRL 6	913.5	+55.5%	Sc2.0 International Consortium, NYU	97/100	🔬 TRL 4-6
#14—	Cell-Free Continuous Biomanufacturing Reactor Dr. Michael Jewett, Dr. Jason Kelly•10.1038/s41467-023-41289-w	Synthetic Biology & Genomics	TRL 6	907.4	+53.1%	Northwestern University, Ginkgo Bioworks	95/100	🔬 TRL 4-6
#15-2	Bacteriophage Generative Engineering Platform Dr. Stanley Qi, Dr. Xavier Duportet•10.1038/s41587-024-02189-1	Synthetic Biology & Genomics	TRL 6	902.6	+24.7%	Stanford, Eligo Bioscience	97/100	📈 SCALING
#16+3	mRNA-LNP Multivalent Universal Influenza & Corona Vaccine Dr. Drew Weissman, Dr. Katalin Karikó•10.1126/science.abm0271	Synthetic Biology & Genomics	TRL 8	898.6	+48.4%	Penn Medicine	95/100	⭐ COMMERCIAL SPINOUT
#17-2	Engineered Nitrogen-Fixing Endophytic Microbes Dr. Christopher Voigt, Dr. Karsten Temme•10.1073/pnas.2309182120	Synthetic Biology & Genomics	TRL 8	890.0	+13.5%	MIT, Pivot Bio	93/100	⭐ COMMERCIAL SPINOUT
#18—	Epigenetic Age Reversal OSK Reprogramming Vector Dr. David Sinclair, Dr. Lu Wang•10.1038/s41586-020-2975-4	Synthetic Biology & Genomics	TRL 5	885.9	+26.3%	Harvard Medical School	93/100	⚡ LAB PROOF
#19-3	Universal Off-The-Shelf Allogeneic CAR-T Platform Dr. Waseem Qasim, Dr. Rachel Haurwitz•10.1038/s41591-023-02501-x	Synthetic Biology & Genomics	TRL 8	881.0	+35.4%	UCL, Caribou Biosciences	94/100	🔬 TRL 4-6
#20+4	Enzymatic Carbon Fixation Cycle (CETCH 2.0) Dr. Tobias Erb, Dr. Nicole Paczia•10.1126/science.aah5237	Synthetic Biology & Genomics	TRL 4	873.6	+16.5%	Max Planck Institute for Terrestrial Microbiology	96/100	⭐ COMMERCIAL SPINOUT
#21—	Aquila 256-Neutral-Atom Quantum Processor Dr. Mikhail Lukin, Dr. Vladan Vuletic•10.1038/s41586-023-06927-3	Quantum Computing	TRL 8	867.0	+15.0%	QuEra Computing, Harvard	97/100	🔬 TRL 4-6
#22+4	Condor 1,121-Qubit Superconducting Quantum Chip Dr. Jay Gambetta, Dr. Jerry Chow•10.1103/PhysRevX.14.011005	Quantum Computing	TRL 6	863.5	+51.0%	IBM Quantum	95/100	⭐ COMMERCIAL SPINOUT
#23+1	Sycamore Topological Surface Code Architecture Dr. Hartmut Neven, Dr. Julian Kelly•10.1038/s41586-022-05434-1	Quantum Computing	TRL 6	856.4	+42.7%	Google Quantum AI	92/100	⚡ LAB PROOF
#24+4	Photonic Fault-Tolerant Silicon Qubit Architecture Dr. Jeremy O'Brien, Dr. Terry Rudolph•10.1126/science.adg8761	Quantum Computing	TRL 6	851.6	+12.6%	PsiQuantum, SLAC	92/100	🔬 TRL 4-6
#25+3	Trapped-Ion H2-1 Quantum Computer (56 Qubits) Dr. Ilyas Khan, Dr. Charlie Baldwin•arXiv:2406.02501	Quantum Computing	TRL 8	843.9	+18.1%	Quantinuum	93/100	⚡ LAB PROOF
#26+3	Majorana Zero-Mode Topological Qubit Core Dr. Chetan Nayak, Dr. Leo Kouwenhoven•10.1103/PhysRevB.107.245423	Quantum Computing	TRL 5	837.7	+39.7%	Microsoft Quantum, Delft	96/100	⭐ COMMERCIAL SPINOUT
#27-2	Silicon Spin Qubit Bilayer Heterostructure Dr. Michelle Simmons, Dr. Andrea Morello•10.1038/s41565-023-01452-9	Quantum Computing	TRL 5	833.2	+15.7%	UNSW Sydney, Silicon Quantum Computing	91/100	🔬 TRL 4-6
#28—	Diamond NV-Center Quantum Repeater Network Dr. Ronald Hanson, Dr. Marko Loncar•10.1038/s41586-021-03505-3	Quantum Computing	TRL 6	827.9	+18.0%	Delft QuTech, Harvard	96/100	⭐ COMMERCIAL SPINOUT
#29+4	Superconducting Fluxonium Qubit Circuitry Dr. Andrew Houck, Dr. Michel Devoret•10.1103/PRXQuantum.4.040301	Quantum Computing	TRL 4	820.6	+13.3%	Princeton University, Yale	92/100	⭐ COMMERCIAL SPINOUT
#30—	Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II) Dr. Rich Uhlig, Dr. Stefano Pellerano•10.1109/JSSC.2023.3289012	Quantum Computing	TRL 7	814.7	+35.7%	Intel Labs, TU Delft	95/100	🔬 TRL 4-6
#31-1	Room-Temperature Ambient Superconductor Candidate Search (LK-Engine) Dr. Mikhail Eremets, Dr. Anand Bhattacharya•10.1038/s41586-023-06673-4	Advanced Materials & Nanotech	TRL 4	810.6	+6.0%	Max Planck Institute for Solid State Research, Argonne	95/100	🔬 TRL 4-6
#32-2	Magic-Angle Twisted Bilayer Graphene Correlated Superlattices Dr. Pablo Jarillo-Herrero, Dr. Philip Kim•10.1038/nature26160	Advanced Materials & Nanotech	TRL 5	804.5	+22.6%	MIT, Harvard	90/100	⚡ LAB PROOF
#33-1	Synthetic Diamond Wafer Semiconductor Substrates (100mm) Dr. Martin Kuball, Dr. Christoph Nebel•10.1002/pssa.202300451	Advanced Materials & Nanotech	TRL 6	799.8	+16.6%	Diamond Foundry, Fraunhofer IAF	93/100	⚡ LAB PROOF
#34+3	Direct Air Capture Metal-Organic Frameworks (CALF-20) Dr. George Shimizu, Dr. Brett Carter•10.1126/science.abi7281	Advanced Materials & Nanotech	TRL 8	793.0	+15.5%	University of Calgary, Svante	95/100	🔬 TRL 4-6
#35—	Self-Healing Vascular Polymeric Structural Composites Dr. Nancy Sottos, Dr. Jeffrey Moore•10.1038/s41563-023-01602-x	Advanced Materials & Nanotech	TRL 6	785.7	+45.7%	UIUC, Autonomous Materials Systems	93/100	⚡ LAB PROOF
#36-1	MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes Dr. Yury Gogotsi, Dr. Michael Naguib•10.1038/s41578-022-00465-1	Advanced Materials & Nanotech	TRL 8	781.7	+39.4%	Drexel University	93/100	⚡ LAB PROOF
#37+4	Metamaterial Acoustic / Optical Cloaking Hyperlens Dr. Xiang Zhang, Dr. Sir John Pendry•10.1126/science.1147231	Advanced Materials & Nanotech	TRL 4	775.0	+34.2%	UC Berkeley, Oxford	93/100	⚡ LAB PROOF
#38—	Aerogel Thermal Barrier (Silica-Polyimide Nanofoam) Dr. Mary Ann Meador, Dr. Stephanie Vivod•10.1021/acsami.2c19012	Advanced Materials & Nanotech	TRL 7	769.3	+42.1%	NASA Glenn, Blueshift Materials	91/100	🔬 TRL 4-6
#39—	Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction Dr. Yadong Li, Dr. Matteo Cargnello•10.1038/s41570-023-00492-3	Advanced Materials & Nanotech	TRL 7	765.2	+21.3%	Tsinghua University, Stanford	93/100	🔬 TRL 4-6
#40-1	Carbon Nanotube Field-Effect Transistor (RV16X-NANO) Dr. Max Shulaker, Dr. Gage Hills•10.1038/s41586-019-1493-0	Advanced Materials & Nanotech	TRL 6	757.9	+21.6%	MIT, Analog Devices	94/100	🔬 TRL 4-6
#41+2	N1 1024-Channel Flexible Thread Intracortical BCI Dr. Matthew MacDougall, Dr. DJ Seo•10.2196/16194	Neuroscience & Brain Interfaces	TRL 6	751.9	+19.9%	Neuralink	93/100	⚡ LAB PROOF
#42+2	Layer 7 Micro-Electrocorticography (uECoG) Thin-Film Array Dr. Benjamin Rapoport, Dr. Mark Richardson•10.1038/s41551-023-01089-w	Neuroscience & Brain Interfaces	TRL 8	745.8	+28.6%	Precision Neuroscience, Mount Sinai	93/100	🔬 TRL 4-6
#43+4	Stentrode Endovascular Brain-Computer Interface Dr. Thomas Oxley, Dr. Nicholas Opie•10.1001/jamaneurol.2022.4847	Neuroscience & Brain Interfaces	TRL 8	739.6	+30.2%	Synchron, Melbourne University	92/100	⭐ COMMERCIAL SPINOUT
#44-2	Neural Replay Non-Invasive Continuous Speech Decoder Dr. Alexander Huth, Dr. Jerry Tang•10.1038/s41593-023-01304-9	Neuroscience & Brain Interfaces	TRL 5	733.6	+32.4%	UT Austin	89/100	⚡ LAB PROOF
#45—	Whole-Brain Synaptic Connectome Imaging (MICrONS) Dr. Jeff Lichtman, Dr. Clay Reid•10.1101/2021.07.28.454025	Neuroscience & Brain Interfaces	TRL 7	728.0	+29.7%	Harvard, Allen Institute, Princeton	91/100	⚡ LAB PROOF
#46+1	Closed-Loop Deep Brain Stimulator (Percept PC Sensing) Dr. Philip Starr, Dr. Edward Chang•10.1038/s41587-021-00897-4	Neuroscience & Brain Interfaces	TRL 8	722.3	+33.2%	Medtronic, UCSF	92/100	🔬 TRL 4-6
#47+1	Optogenetic Cortical Restoration of Vision Dr. Jose-Alain Sahel, Dr. Botond Roska•10.1038/s41591-021-01351-4	Neuroscience & Brain Interfaces	TRL 6	717.2	+20.8%	Institut de la Vision, GenSight	88/100	🔬 TRL 4-6
#48-2	Organoid Intelligence (OI) Brain-on-Chip Biocomputer Dr. Thomas Hartung, Dr. Brett Kagan•10.3389/fsci.2023.1017235	Neuroscience & Brain Interfaces	TRL 4	711.8	+22.8%	Johns Hopkins, Cortical Labs	88/100	⭐ COMMERCIAL SPINOUT
#49+3	Focused Ultrasound Blood-Brain Barrier Opening System Dr. Kullervo Hynynen, Dr. Nir Lipsman•10.1038/s41467-023-38823-1	Neuroscience & Brain Interfaces	TRL 8	706.3	+37.2%	Sunnybrook, Insightec	92/100	⚡ LAB PROOF
#50—	Spinal Cord Neuroprosthetic Epidural Stimulation Dr. Gregoire Courtine, Dr. Jocelyne Bloch•10.1038/s41586-023-06094-5	Neuroscience & Brain Interfaces	TRL 6	698.7	+10.6%	EPFL, Lausanne University Hospital	90/100	🔬 TRL 4-6

#1+3

AlphaFold 3 Biomolecular Structure Engine

10.1038/s41586-024-07487-w

SMS Score

984.5 /1000

30D Surge

+32.4%

NASA TRL

TRL 9

Domain

AI for Science

#2+4

ESM-3 98B Generative Biology Foundation Model

arXiv:2406.20092

SMS Score

977.6 /1000

30D Surge

+7.0%

NASA TRL

TRL 6

Domain

AI for Science

#3—

GNoME Materials Discovery Graph Network

10.1038/s41586-023-06735-9

SMS Score

973.1 /1000

30D Surge

+45.8%

NASA TRL

TRL 8

Domain

AI for Science

#4—

RFdiffusion De Novo Protein Generator

10.1038/s41586-023-06415-8

SMS Score

968.0 /1000

30D Surge

+25.8%

NASA TRL

TRL 8

Domain

AI for Science

#5+2

GraphCast Global 10-Day AI Weather Forecaster

10.1126/science.adi2336

SMS Score

960.5 /1000

30D Surge

+9.9%

NASA TRL

TRL 9

Domain

AI for Science

#6-3

DeepPotential Molecular Dynamics (DP-MD)

arXiv:2308.12001

SMS Score

955.1 /1000

30D Surge

+38.0%

NASA TRL

TRL 8

Domain

AI for Science

#7+2

AlphaGeometry Automated Olympiad Geometry Solver

10.1038/s41586-023-06747-5

SMS Score

948.2 /1000

30D Surge

+39.8%

NASA TRL

TRL 6

Domain

AI for Science

#8-1

BioNeMo Generative Drug Discovery Supercomputing

10.1109/MCSE.2024.33

SMS Score

944.5 /1000

30D Surge

+49.5%

NASA TRL

TRL 8

Domain

AI for Science

#9-2

Orbital-Net Physics-Informed Spacecraft Autonomy

10.2514/1.G007123

SMS Score

939.0 /1000

30D Surge

+18.3%

NASA TRL

TRL 6

Domain

AI for Science

#10—

OpenFold Open-Source Trainable AlphaFold2

10.1038/s41592-024-02206-8

SMS Score

931.9 /1000

30D Surge

+29.0%

NASA TRL

TRL 9

Domain

AI for Science

#11-3

CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator

10.1126/science.aba9381

SMS Score

926.4 /1000

30D Surge

+38.0%

NASA TRL

TRL 7

Domain

Synthetic Biology & Genomics

#12-3

Prime Editing 3b Non-Viral Genomic Correction

10.1038/s41587-023-01928-y

SMS Score

921.8 /1000

30D Surge

+21.3%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#13+2

Synthetic Yeast Genome Sc2.0 (16-Chromosome)

10.1016/j.cell.2023.10.015

SMS Score

913.5 /1000

30D Surge

+55.5%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#14—

Cell-Free Continuous Biomanufacturing Reactor

10.1038/s41467-023-41289-w

SMS Score

907.4 /1000

30D Surge

+53.1%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#15-2

Bacteriophage Generative Engineering Platform

10.1038/s41587-024-02189-1

SMS Score

902.6 /1000

30D Surge

+24.7%

NASA TRL

TRL 6

Domain

Synthetic Biology & Genomics

#16+3

mRNA-LNP Multivalent Universal Influenza & Corona Vaccine

10.1126/science.abm0271

SMS Score

898.6 /1000

30D Surge

+48.4%

NASA TRL

TRL 8

Domain

Synthetic Biology & Genomics

#17-2

Engineered Nitrogen-Fixing Endophytic Microbes

10.1073/pnas.2309182120

SMS Score

890.0 /1000

30D Surge

+13.5%

NASA TRL

TRL 8

Domain

Synthetic Biology & Genomics

#18—

Epigenetic Age Reversal OSK Reprogramming Vector

10.1038/s41586-020-2975-4

SMS Score

885.9 /1000

30D Surge

+26.3%

NASA TRL

TRL 5

Domain

Synthetic Biology & Genomics

#19-3

Universal Off-The-Shelf Allogeneic CAR-T Platform

10.1038/s41591-023-02501-x

SMS Score

881.0 /1000

30D Surge

+35.4%

NASA TRL

TRL 8

Domain

Synthetic Biology & Genomics

#20+4

Enzymatic Carbon Fixation Cycle (CETCH 2.0)

10.1126/science.aah5237

SMS Score

873.6 /1000

30D Surge

+16.5%

NASA TRL

TRL 4

Domain

Synthetic Biology & Genomics

#21—

Aquila 256-Neutral-Atom Quantum Processor

10.1038/s41586-023-06927-3

SMS Score

867.0 /1000

30D Surge

+15.0%

NASA TRL

TRL 8

Domain

Quantum Computing

#22+4

Condor 1,121-Qubit Superconducting Quantum Chip

10.1103/PhysRevX.14.011005

SMS Score

863.5 /1000

30D Surge

+51.0%

NASA TRL

TRL 6

Domain

Quantum Computing

#23+1

Sycamore Topological Surface Code Architecture

10.1038/s41586-022-05434-1

SMS Score

856.4 /1000

30D Surge

+42.7%

NASA TRL

TRL 6

Domain

Quantum Computing

#24+4

Photonic Fault-Tolerant Silicon Qubit Architecture

10.1126/science.adg8761

SMS Score

851.6 /1000

30D Surge

+12.6%

NASA TRL

TRL 6

Domain

Quantum Computing

#25+3

Trapped-Ion H2-1 Quantum Computer (56 Qubits)

arXiv:2406.02501

SMS Score

843.9 /1000

30D Surge

+18.1%

NASA TRL

TRL 8

Domain

Quantum Computing

#26+3

Majorana Zero-Mode Topological Qubit Core

10.1103/PhysRevB.107.245423

SMS Score

837.7 /1000

30D Surge

+39.7%

NASA TRL

TRL 5

Domain

Quantum Computing

#27-2

Silicon Spin Qubit Bilayer Heterostructure

10.1038/s41565-023-01452-9

SMS Score

833.2 /1000

30D Surge

+15.7%

NASA TRL

TRL 5

Domain

Quantum Computing

#28—

Diamond NV-Center Quantum Repeater Network

10.1038/s41586-021-03505-3

SMS Score

827.9 /1000

30D Surge

+18.0%

NASA TRL

TRL 6

Domain

Quantum Computing

#29+4

Superconducting Fluxonium Qubit Circuitry

10.1103/PRXQuantum.4.040301

SMS Score

820.6 /1000

30D Surge

+13.3%

NASA TRL

TRL 4

Domain

Quantum Computing

#30—

Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II)

10.1109/JSSC.2023.3289012

SMS Score

814.7 /1000

30D Surge

+35.7%

NASA TRL

TRL 7

Domain

Quantum Computing

#31-1

Room-Temperature Ambient Superconductor Candidate Search (LK-Engine)

10.1038/s41586-023-06673-4

SMS Score

810.6 /1000

30D Surge

+6.0%

NASA TRL

TRL 4

Domain

Advanced Materials & Nanotech

#32-2

Magic-Angle Twisted Bilayer Graphene Correlated Superlattices

10.1038/nature26160

SMS Score

804.5 /1000

30D Surge

+22.6%

NASA TRL

TRL 5

Domain

Advanced Materials & Nanotech

#33-1

Synthetic Diamond Wafer Semiconductor Substrates (100mm)

10.1002/pssa.202300451

SMS Score

799.8 /1000

30D Surge

+16.6%

NASA TRL

TRL 6

Domain

Advanced Materials & Nanotech

#34+3

Direct Air Capture Metal-Organic Frameworks (CALF-20)

10.1126/science.abi7281

SMS Score

793.0 /1000

30D Surge

+15.5%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#35—

Self-Healing Vascular Polymeric Structural Composites

10.1038/s41563-023-01602-x

SMS Score

785.7 /1000

30D Surge

+45.7%

NASA TRL

TRL 6

Domain

Advanced Materials & Nanotech

#36-1

MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes

10.1038/s41578-022-00465-1

SMS Score

781.7 /1000

30D Surge

+39.4%

NASA TRL

TRL 8

Domain

Advanced Materials & Nanotech

#37+4

Metamaterial Acoustic / Optical Cloaking Hyperlens

10.1126/science.1147231

SMS Score

775.0 /1000

30D Surge

+34.2%

NASA TRL

TRL 4

Domain

Advanced Materials & Nanotech

#38—

Aerogel Thermal Barrier (Silica-Polyimide Nanofoam)

10.1021/acsami.2c19012

SMS Score

769.3 /1000

30D Surge

+42.1%

NASA TRL

TRL 7

Domain

Advanced Materials & Nanotech

#39—

Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction

10.1038/s41570-023-00492-3

SMS Score

765.2 /1000

30D Surge

+21.3%

NASA TRL

TRL 7

Domain

Advanced Materials & Nanotech

#40-1

Carbon Nanotube Field-Effect Transistor (RV16X-NANO)

10.1038/s41586-019-1493-0

SMS Score

757.9 /1000

30D Surge

+21.6%

NASA TRL

TRL 6

Domain

Advanced Materials & Nanotech

#41+2

N1 1024-Channel Flexible Thread Intracortical BCI

10.2196/16194

SMS Score

751.9 /1000

30D Surge

+19.9%

NASA TRL

TRL 6

Domain

Neuroscience & Brain Interfaces

#42+2

Layer 7 Micro-Electrocorticography (uECoG) Thin-Film Array

10.1038/s41551-023-01089-w

SMS Score

745.8 /1000

30D Surge

+28.6%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#43+4

Stentrode Endovascular Brain-Computer Interface

10.1001/jamaneurol.2022.4847

SMS Score

739.6 /1000

30D Surge

+30.2%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#44-2

Neural Replay Non-Invasive Continuous Speech Decoder

10.1038/s41593-023-01304-9

SMS Score

733.6 /1000

30D Surge

+32.4%

NASA TRL

TRL 5

Domain

Neuroscience & Brain Interfaces

#45—

Whole-Brain Synaptic Connectome Imaging (MICrONS)

10.1101/2021.07.28.454025

SMS Score

728.0 /1000

30D Surge

+29.7%

NASA TRL

TRL 7

Domain

Neuroscience & Brain Interfaces

#46+1

Closed-Loop Deep Brain Stimulator (Percept PC Sensing)

10.1038/s41587-021-00897-4

SMS Score

722.3 /1000

30D Surge

+33.2%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#47+1

Optogenetic Cortical Restoration of Vision

10.1038/s41591-021-01351-4

SMS Score

717.2 /1000

30D Surge

+20.8%

NASA TRL

TRL 6

Domain

Neuroscience & Brain Interfaces

#48-2

Organoid Intelligence (OI) Brain-on-Chip Biocomputer

10.3389/fsci.2023.1017235

SMS Score

711.8 /1000

30D Surge

+22.8%

NASA TRL

TRL 4

Domain

Neuroscience & Brain Interfaces

#49+3

Focused Ultrasound Blood-Brain Barrier Opening System

10.1038/s41467-023-38823-1

SMS Score

706.3 /1000

30D Surge

+37.2%

NASA TRL

TRL 8

Domain

Neuroscience & Brain Interfaces

#50—

Spinal Cord Neuroprosthetic Epidural Stimulation

10.1038/s41586-023-06094-5

SMS Score

698.7 /1000

30D Surge

+10.6%

NASA TRL

TRL 6

Domain

Neuroscience & Brain Interfaces

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Breakthrough Research 100

AlphaFold 3 Biomolecular Structure Engine

ESM-3 98B Generative Biology Foundation Model

GNoME Materials Discovery Graph Network

RFdiffusion De Novo Protein Generator

GraphCast Global 10-Day AI Weather Forecaster

DeepPotential Molecular Dynamics (DP-MD)

AlphaGeometry Automated Olympiad Geometry Solver

BioNeMo Generative Drug Discovery Supercomputing

Orbital-Net Physics-Informed Spacecraft Autonomy

OpenFold Open-Source Trainable AlphaFold2

CRISPR-Cas12a & Cas13 RNA/DNA Epigenome Modulator

Prime Editing 3b Non-Viral Genomic Correction

Synthetic Yeast Genome Sc2.0 (16-Chromosome)

Cell-Free Continuous Biomanufacturing Reactor

Bacteriophage Generative Engineering Platform

mRNA-LNP Multivalent Universal Influenza & Corona Vaccine

Engineered Nitrogen-Fixing Endophytic Microbes

Epigenetic Age Reversal OSK Reprogramming Vector

Universal Off-The-Shelf Allogeneic CAR-T Platform

Enzymatic Carbon Fixation Cycle (CETCH 2.0)

Aquila 256-Neutral-Atom Quantum Processor

Condor 1,121-Qubit Superconducting Quantum Chip

Sycamore Topological Surface Code Architecture

Photonic Fault-Tolerant Silicon Qubit Architecture

Trapped-Ion H2-1 Quantum Computer (56 Qubits)

Majorana Zero-Mode Topological Qubit Core

Silicon Spin Qubit Bilayer Heterostructure

Diamond NV-Center Quantum Repeater Network

Superconducting Fluxonium Qubit Circuitry

Cryogenic CMOS Quantum Controller ASIC (Horse Ridge II)

Room-Temperature Ambient Superconductor Candidate Search (LK-Engine)

Magic-Angle Twisted Bilayer Graphene Correlated Superlattices

Synthetic Diamond Wafer Semiconductor Substrates (100mm)

Direct Air Capture Metal-Organic Frameworks (CALF-20)

Self-Healing Vascular Polymeric Structural Composites

MXene 2D Transition Metal Carbide Pseudocapacitive Electrodes

Metamaterial Acoustic / Optical Cloaking Hyperlens

Aerogel Thermal Barrier (Silica-Polyimide Nanofoam)

Single-Atom Catalysts (SAC) for Carbon-to-Ethylene Reduction

Carbon Nanotube Field-Effect Transistor (RV16X-NANO)

N1 1024-Channel Flexible Thread Intracortical BCI

Layer 7 Micro-Electrocorticography (uECoG) Thin-Film Array

Stentrode Endovascular Brain-Computer Interface

Neural Replay Non-Invasive Continuous Speech Decoder

Whole-Brain Synaptic Connectome Imaging (MICrONS)

Closed-Loop Deep Brain Stimulator (Percept PC Sensing)

Optogenetic Cortical Restoration of Vision

Organoid Intelligence (OI) Brain-on-Chip Biocomputer

Focused Ultrasound Blood-Brain Barrier Opening System

Spinal Cord Neuroprosthetic Epidural Stimulation

Unlock Full Top 100 Scientific Indices (#51–#100)